Structural Diversity of Streptokinase and Activation of Human Plasminogen
2005
Lizano, Sergio | Johnston, Kenneth H.
The {szligbeta} domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.
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