Phytochemical Investigation and Cytotoxic Evaluation of Components of Leaves and Stems of Machilus zuihoensis var. mushaensis
2014
Lin, Rong-Jyh | Cheng, Ming-Jen | Leung, Katrina | Pan, Cheng-Yi | Chang, Wan-Ting | Hsui, Yen-Ray | Hung, Hsi-Chou | Lo, Wen-Li
From the MeOH extract of the leaves and stems of Machilus zuihoensis var. mushaensis, one new lignan, machilolin-B (1), together with 10 known compounds, zuonin B (2), (+)-9,9′-O-diferuloylsecoisolariciresinol (3), (E)-3-(3-hydroxybut-1-enyl)-2,4,4-trimethylcyclohexa-2,5-dienone (4), 5-[(1R,5R,8S)-8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo[3.2.1]oct-8-yl]-3-methyl-2,4-pentadienoic acid (5), vanillin (6), rhamnetin-3-O-β-D-galactopyranoside (7), 2-hydroxy-3,4-dioxopentanal (8), a mixture of β-sitosterol (9) and stigmasterol (10), and β-sitosteryl-β-D-glucoside (11), have been isolated. Among them, compound 3 was demonstrated to have significant cytotoxic activity against the DU145, LNCaP, and A549 cell lines. Compound 11 also possessed moderate antiproliferative activities against DU145 cell lines.
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