LITTLE KEVIN: a program for the estimation of protein homology by analysing the amino acid compositions and sequences
1996
Grillasca, J.P. | Aubert, D. | Planells, R. | Domingo, N. | Lafont, H.
We present here a computational method based on the analysis of amino acid composition for performing comparisons between proteins. This user-friendly and reliable test is aimed at rapidly identifying, from data-base subsets, sequences--if necessary, partial sequences--which share similar amino acid compositions to the input composition (deduced from experimental results). Apparent molecular weight (as determined by SDS-PAGE) and artefactual modifications due to the experimental determination of the amino acid composition are taken into account to perform the comparison. This program thus constitutes a useful tool in searching for the probable identification of either nonsequenced proteins or peptides from hydrolysed proteins.
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