HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance
2011
Kim, Ha-jung | Kim, Hong-Min | Kim, Chu-Sook | Jeong, Choon-Soo | Choi, Hye-Sun | Kawada, Teruo | Kim, Byung-Sam | Yu, Rina
HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induced obesity. Feeding a high-fat diet (HFD) to HVEM-deficient mice elicited a reduction in the number of macrophages and T cells infiltrated into adipose tissue. Proinflammatory cytokine levels in the adipose tissue decreased in HFD-fed HVEM-deficient mice, while levels of the anti-inflammatory cytokine IL-10 increased. Moreover, glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice. These findings indicate that HVEM may be a useful target for combating obesity-induced inflammatory responses and insulin resistance.
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