The possible litholytic effect of Ononis Spinosa L. on various human kidney stones—An in vitro experimental evaluation
2020
Bashan, Ibrahim | Bozlu, Murat
Urolithiasis is a widespread health problem with a high recurrence and is a clinical condition that can progress to renal failure. This study aimed to investigate whether Ononis spinosa L. has a litholytic effect on kidney stones with different chemical patterns.Urinary stones extracted from seven patients over 18 years of age during surgery were used as the study material. Each urinary stone was divided into two parts, one of which was left in a solution prepared with O. spinosa L. and the other constituted the control sample. The amount of calcium, phosphor and uric acid passing through each solution was detected by spectrophotometric analysis to assess its efficiency and determine whether or not the urinary stones were dissolved in the solution. The chemical compositions of the urinary stones were analyzed using reflectance Fourier transform infrared spectroscopy. To the best of our knowledge, this is the first study to investigate the litholytic effect of O. spinosa L. on kidney stones.The passage of calcium, phosphate and uric acid through the solution containing O. spinosa L. was found to be statistically significant by spectrophotometry (p < 0.05) for all seven kidney stone samples left in the solution, and it was observed that the dissolution rates of the four stones with uric acid were higher than others.The results of this study showed that O. spinosa L. may have a litholytic effect on kidney stones.
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