Change in the Concentration of Vitamins C and E in Rat Tissues by Paraquat Administration
2003
IKEDA, Kazumi | KUMAGAI, Yumi | NAGANO, Yuka | MATSUZAWA, Naoko | KOJO, Shosuke
Paraquat causes lung injury by oxidative stress. After 48 h of intraperitoneal administration of paraquat (50 mg/kg of body weight) to rats, the vitamin C concentration in the lungs was significantly decreased, while lung vitamin E content was increased after 12 h. These results indicate that vitamin C directly reflected the oxidative stress in the lungs.
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