Estimation of unbiased recombination values in the presence of misclassification of a trait using RFLP maps
1996
Cheng, R. | Takano, Y. | Saito, A. | Ukai, Y.
The effect of misclassification of phenotypes of a trait on the estimation of recombination value was investigated. The effect was larger for closer linkage. If a locus is dominant and linked with the misclassified trait locus in the repulsion phase, then the effect on the recombination value between the two loci is largest. A method for estimating the unbiased recombination value and the misclassification rate using maximum likelihood associated with an EM algorithm is also presented. This method was applied to a numerical example from rice genome data. It was concluded that the present method combined with the metric multi-dimensional scaling method is useful for the detection of misclassified markers and for the estimation of unbiased recombination values.
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