Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca

Salisbury, M.A.R.; Kaswan, R.L.; Brown, J.

Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca

1995

Salisbury, M.A.R. | Kaswan, R.L. | Brown, J.

The effect that topical administration of cyclosporine would have on the number and type of microorganisms isolated from the corneal surface of dogs with keratoconjunctivitis sicca was studied. Schirmer tear tests were performed on and corneal swab specimens were collected from 61 eyes of 31 dogs with keratoconjunctivitis sicca prior to and after 3, 6, and 12 months of treatment with cyclosporine. In eyes that responded to cyclosporine treatment (Schirmer tear test value increased by greater than or equal to 5 mm/min, compared with pretreatment value), the percentage of eyes from which bacteria were isolated after 3, 6, and 12 months of treatment was significantly (P < 0.001) less than the percentage from which bacteria were isolated prior to treatment. However, among eyes that did not respond to treatment, we did not detect a significant change over time in prevalence of bacteria or type of bacteria isolated. The percentage of eyes from which fungi were isolated decreased during treatment; however, the small number of eyes in which fungal culture results were initially positive precluded demonstration of a significant change. For all eyes, we did not detect any significant differences over time in the frequency with which specific bacterial genera were isolated, with the exception of beta-hemolytic Streptococcus spp. Opportunistic corneal infections were not detected even though none of the dogs received antibiotics. An increase in production of tears, which contain anti-infection proteins, was believed to be the primary factor responsible for the decrease in the percentage of eyes from which microorganisms could be isolated.

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Mots clés AGROVOC

animals bacteria cornea cornea dogs dogs drug therapy eyes fungi georgia immunosuppression keratoconjunctivitis microbiology microorganisms north carolina south carolina staphylococcus streptococcus tears topical application

Informations bibliographiques

Publié dans

American journal of veterinary research

Volume 56 Numéro 7 Pagination 880 - 884 ISSN 0002-9645

Editeur

American Entomological Society

D'autres materias

Opportunistic infections; Cyclosporins; Therapeutic use; Isolation & purification; Keratoconjunctivitis sicca; Opportunistic infections; Cyclosporine; Reference values; Dog diseases; Veterinary; Drug effects

Langue

anglais

Note

2019-12-05

Type

Text; Journal Article

Sur AGRIS depuis: 2024-02-28

Format: MODS

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