Antifungal activity of alkanols against Zygosaccharomyces bailii and their effects on fungal plasma membrane
2008
Fujita, Ken-ichi | Fujita, Tomoko | Kubo, Isao
A series of aliphatic primary alkanols from C₆ to C₁₃ were tested for antifungal activity against a food spoilage fungus Zygosaccharomyces bailii using a broth dilution method and were compared for their effects against Saccharomyces cerevisiae and Z. rouxii. Decanol (C₁₀) was found to be the most potent fungicide against Z. bailii at a minimum fungicidal concentration of 50 μg/ml (0.31 mM), whereas undecanol (C₁₁) was found to be the most potent fungistatic at a minimum inhibitory concentration of 25 μg/ml (0.14 mM). The time-kill curve study showed that decanol was fungicidal against Z. bailii at any growth stage. Octanol (C₈) increased plasma membrane fluidity in the spheroplast cells of S. cerevisiae. The primary antifungal action of alkanols comes from their ability to disrupt the native membrane-associated function of integral proteins nonspecifically as nonionic surface-active agents (surfactants). The antifungal activity of decanol against Z. bailii was slightly enhanced in combination with anethole.
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