The Genome of the Kinetoplastid Parasite, Leishmania major
2005
Ivens, Alasdair C. | Peacock, Christopher S. | Worthey, Elizabeth A. | Murphy, Lee | Aggarwal, Gautam | Berriman, Matthew | Sisk, Ellen | Rajandream, Marie-Adele | Adlem, Ellen | Aert, Rita | Anupama, Atashi | Apostolou, Zina | Attipoe, Philip | Bason, Nathalie | Bauser, Christopher | Beck, Alfred | Beverley, Stephen M. | Bianchettin, Gabriella | Borzym, Katja | Bothe, Gordana | Bruschi, Carlo V. | Collins, Matt | Cadag, Eithon | Ciarloni, Laura | Clayton, Christine | Coulson, Richard M. R. | Cronin, Ann | Cruz, Angela K. | Davies, Robert M. | De Gaudenzi, Javier | Dobson, Deborah E. | Duesterhoeft, Andreas | Fazelina, Gholam | Fosker, Nigel | Frasch, Alberto Carlos | Fraser, Audrey | Fuchs, Monika | Gabel, Claudia | Goble, Arlette | Goffeau, André | Harris, David | Hertz-Fowler, Christiane | Hilbert, Helmut | Horn, David | Hoàng, Dĩ Đình | Klages, Sven | Knights, Andrew | Kube, Michael | Larke, Natasha | Litvin, Lyudmila | Lord, Angela | Louie, Tin | Marra, Marco | Masuy, David | Matthews, Keith | Michaeli, Shulamit | Mottram, Jeremy C. | Můller-Auer, Silke | Munden, Heather | Nelson, Siri | Norbertczak, Halina | Oliver, Karen | O'Neil, Susan | Pentony, Martin | Pohl, Thomas M. | Price, Claire | Purnelle, Bénédicte | Quail, Michael A. | Rabbinowitsch, Ester | Reinhardt, Richard | Rieger, Michael | Rinta, Joel | Robben, Johan | Robertson, Laura | Ruiz, Jeronimo C. | Rutter, Simon | Saunders, David | Schäfer, Melanie | Schein, Jacquie | Schwartz, David C. | Seeger, Kathy | Seyler, Amber | Sharp, Sarah | Shin, Heesun | Sivam, Dhileep | Squares, Rob | Squares, Steve | Tosato, Valentina | Vogt, Christy | Volckaert, Guido | Wambutt, Rolf | Warren, Tim | Wedler, Holger | Woodward, John | Zhou, Shiguo | Zimmermann, Wolfgang | Smith, Deborah F. | Blackwell, J. M. (Jenefer M) | Stuart, Kenneth D. | Barrell, Bart | Myler, Peter J.
Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
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