Toxoplasmosis: A history of clinical observations
2009
Weiss, Louis M. | Dubey, Jitender. P.
It has been 100years since Toxoplasma gondii was initially described in Tunis by in the tissues of the gundi (Ctenodoactylus gundi) and in Brazil by in the tissues of a rabbit. Toxoplasma gondii is a ubiquitous, Apicomplexan parasite of warm-blooded animals that can cause several clinical syndromes including encephalitis, chorioretinitis, congenital infection and neonatal mortality. Fifteen years after the description of T. gondii by Nicolle and Manceaux a fatal case of toxoplasmosis in a child was reported by Janků. In 1939 Wolf, Cowen and Paige were the first to conclusively identify T. gondii as a cause of human disease. This review examines the clinical manifestations of infection with T. gondii and the history of the discovery of these manifestations.
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