Nutraceutical potential of navel orange peel in diabetes management: The chemical profile, antioxidant, α-glucosidase inhibitory and antiglycation effects of its flavonoids
2022
Zhang, Jun | Zhang, Linyan | Lai, Chunling | Liang, Yan | Gao, Liangliang | Kaliaperumal, Kumaravel | Jiang, Yueming
Oxidative damage, chronic hyperglycemia, and the formation of advanced glycation end products (AGEs) are important risk factors associated closely with diabetes and its complications. In the present study, the antidiabetic potential of navel orange peel was explored for the first time by evaluating the antioxidant, α-glucosidase inhibition, and antiglycation activities of its extracts and individual flavonoids. In total, seventeen flavonoids were identified from the peel extract, of which 5-hydroxy-6,7,3′,4′-tetramethoxyflavone, didymin and sinensetin were the most potent antioxidant, α-glucosidase inhibitor, and glycation inhibitor, respectively. In addition, the structure-activity relationship (SAR) studies of these flavonoids were performed in detail. Moreover, the most potent antidiabetic extract of navel orange peel was quantitatively analyzed by HPLC. The present results support the potent application of orange peel as a nutraceutical resource for diabetes management, and might be beneficial to the orange juice industry by providing useful information on the valorization of orange peel.
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