Hypophosphatemic rickets: Effect of 1alpha, 25-dihydroxyvitamin D3 on growth and mineral metabolism
1979
Chan, James C.M. | Bartter, Frederic C.
Vitamin D-resistant hypophosphatemic rickets was diagnosed in a 5 year old boy which did not respond to the accepted treatment of massive doses of vitamin D2. At age 6, vitamin doses were increased and supplemented with calcium carbonate and buffered phosphate. Growth retardation was severe and spontaneous tooth abcesses occurred. At the age of 16, the patient began receiving 1alpha,25-dihydroxyvitamin D3. Serum phosphorus rose in spite of a 50% decrease in supplementation. Height increased from 3rd percentile to 25th percentile. Radiology revealed healing of rickets. Urinary and stool phosphorus was reduced; no hypercalcemia was noted. The 1alpha,25-dihydroxyvitamin D3 stimulates intestinal absorption of calcium and improves calcium-phosphorus balance. It is effective within a few hours and seems to be an effective alternative to massive vitamin therapy.
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