Klassische Synthese von Thymopoietin 32-36 (TP 5) unter Verwendung der säurelabilen 1- (1 -Adamantyl) -1 -methylethoxycarbonyl- Schutzgruppe+ / Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1 -(1 - Adamantyl)-1 -methylethoxycarbonyl Group
2014
Heinzel, Wolfgang | Kronbach, Thomas | Voelter, W.
A synthesis of high yields of TP 5 is described. The a-amino functions were blocked by the acid-labile 1-(1 -adamantyl)-1-methylethoxycarbonyl-(Adpoc)group. The Adpoc group is cleaved under mild acidolytic conditions with 3% TFA in CH₂CI₂ while the tert-butyl residues remained intact. This selective cleavage of the Adpoc group compared with the Boc and tert-butyl residues allows new strategies for the synthesis of large peptides
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