Changes in the Number and Apoptosis of Epithelial Cells in the Colorectum of Wheat Bran-fed Rats Soon after Administering 1,2-Dimethylhydrazine
1997
Ishizuka, Satoshi | Sonoyama, Kei | Kasai, Takanori
We investigated the effect of dietary wheat bran (Wb) on colonic tumorigenesis soon after a single administration of 1,2-dimethyIhydrazine (DMH). Rats that had been fed on either a fiber-free diet or a 20% Wb diet were injected with 1,2-dimethylhydrazine (20mg/kg body weight). At 6 h, 12 h, 1 d, 3 d, or 7 d after the injection, the colorectum was excised for histological analyses. The number of crypt cells more rapidly recovered in the 20% Wb group than in the fiber-free group after its temporary reduction by injection of DMH. At 6 h after the DMH treatment, the apoptotic cells were significantly greater in number in the fiber-free group than in the 20% Wb group. In contrast, those in distal colon were significantly fewer in the fiber-free group than in the 20% Wb group at 7 d after the treatment. These results suggest that the ingestion of Wb affected the turnover of colonic epithelial cells and would thereby bring about a protective effect against DMH-induced tumorigenesis.
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