Two New Flavonol Glycosides as DNA Topoisomerase I Poisons
2014
López-Lázaro, Miguel | Martín-Cordero, Carmen | Ayuso, María Jesús
Flavonoids are secondary plant metabolites whose anticancer properties are actually being studied from an epidemiological and pharmacological point of view. They are believed to be implicated in the lower risk of some forms of cancer observed in Asian countries, due to their capacity to control cell proliferation, to act on certain regulatory enzymes as protein kinases or topoisom erases. Based on these precedents, three flavonols isolated from a cytotoxic butanol extract from Retama sphaerocarpa Boissier have been assessed to study their topoisom erase I and II activity. Two new rhamnazin glycosides were found to have the ability to stabilize the cleavage com plex hum an D N A topoisom erase I at concentrations in the 100- 250 μm range, acting as topoisom ersase I poisons.
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