Residue depletion studies on danofloxacin in the chicken
1994
Lynch, M.J. | Rice, J.R. | Ericson, J.F. | Mosher, F.R. | Millas, W.J. | Harran, L.P. | Frame, G.M. | Illyes, E.F. | McGuirk, P.R. | Jefson, M.R.
Penetration of danofloxacin into tissues is consistent with oral bioavailability and pharmacokinetic plasma data derived from chickens given danofloxacin by iv bolus and oral gavage administration at 5 mg/kg. This pharmacokinetic assessment was confirmed when [3H]danofloxacin was administered to broilers in drinking water at 25 microgram/mL for 5 days, and tissues were assayed for residues. Under this regimen, total residues of danofloxacin were higher in liver than other tissues and declined in liver from 0.612 microgram/g at 6 h too 0.056 microgram/g by 48 h of withdrawal, suggesting rapid depletion. In kidney and muscle total residues depleted in parallel with liver but were 2- and 10-fold lower, respectively. The major residue in all tissues was unchanged danofloxacin. An N-demethyl metabolite was found in liver and excreta but was not detected in muscle or fat/skin, indicating that it is an excretory metabolite. The depletion of unchanged and N-demethyl metabolite residues from edible tissues of the chicken was confirmed by HPLC with fluorescence detection when danofloxacin was given to 3-week-old chickens under a commercial use condition, i.e., in drinking water for 3 days at 5 mg/kg of body weight per day.
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