In vitro susceptibility of feline herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine

Nasisse, M.P.; Guy, J.S.; Davidson, M.G.; Sussman, W.; Clercq, E. de

In vitro susceptibility of feline herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine

1989

Nasisse, M.P. | Guy, J.S. | Davidson, M.G. | Sussman, W. | Clercq, E. de

In vitro activities of 9-([2-hydroxyethoxy] methyl) guanine (acyclovir), (E)-5-(2-bromovinyl)-2'deoxyuridine, 9-beta-D-arabinofuranosyladenine (vidarabine), 5-iodo-2'-deoxyuridine (idoxuridine), and 5-trifluoromethyl-2'-deoxyuridine (trifluridine) were studied against 6 strains of feline herpesvirus-1. A significant difference was not detected among viral strains in their susceptibility to these compounds (P = 0.442). The relative potency of these compounds was trifluridine greater than greater than idoxuridine greater than virdarabine greater than bromovinyldeoxyuridine greater than greater than acyclovir. Concentrations of trifluridine and idoxuridine (0.67 and 6.8 micromole, respectively) required to reduce plaque numbers by 50%, compared with that of controls, were significantly lower (P less than 0.001) than were those of other compounds.

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