In vitro and in vivo trypanocidal action of aescin and aescin liposomes against Trypanosoma evansi in experimental mice
2014
Dellaméa Baldissera, Matheus | Bottari, Nathieli Bianchin | Grando, Thirssa Helena | Santos, Roberto Christ Vianna | Dalcin, Ana Júlia Figueiró | Gomes, Patricia | Raffin, Renata Platcheck | Zimmerman, Carine Eloise Prestes | Santurio, Janio Morais | Monteiro, Silvia Gonzalez | Da Silva, Aleksandro Schafer
To verify the trypanocidal effectiveness of aescin and aescin liposomes against Trypanosoma evansi in vitro and in vivo.Aescin and aescin liposomes were used in vitro on trypomastigotes at different concentrations (0.5%, 1.0% and 2.0%) and exposure times (0, 1, 3, 6 and 9 h). In vivo tests were performed using mice as the experimental model. Trypanosome evansi infected mice were treated with aescin and aescin liposomes with doses of 60 and 100 mg/kg during 4 d.The three concentrations tested in free form and nanoencapsulated showed trypanocidal activity in vitro, completely eliminating the parasites in small concentration after 6 h of assay. Animals treated with aescin (100 mg/kg) and aescin liposomes (100 mg/kg) showed increase in longevity, however without curative effect.Active compounds present in natural products, such as aescin, may potentiate the treatment of trypanosomosis when used in association with other trypanocidal drugs.
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