Development of methodologies for the regioselective synthesis of four series of regioisomer isoxazoles from β-enamino diketones
2018
Silva, Raí G. M. | da Silva, Michael J. V. | Jacomini, Andrey P. | Moura, Sidnei | Back, Davi F. | Basso, Ernani A. | Rosa, Fernanda A.
Four methodologies are reported for the regioselective synthesis of four series of regioisomer isoxazoles from cyclocondensation of β-enamino diketones and hydroxylamine hydrochloride. Regiochemical control was achieved by varying reaction conditions and substrate structure. The mild reaction conditions used to access 4,5-disubstituted, 3,4-disubtituted, and 3,4,5-trisubstituted regioisomer isoxazoles, as well as the pharmacological and synthetic potential of the products, make these novel methodologies very powerful.
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