Vitamin E, vitamin A and essential fatty acid status of patients hospitalized for anorexia nervosa
1985
Langan, Susan M. | Farrell, Philip M.
Extract: A group of 17 patients hospitalized for anorexia nervosa was assessed for available status with respect to the essential fatty acids and vitamins E and A. Plasma aliquots available from blood drawn upon hospital admission were frozen and later extracted for total phospholipids (PL). The fatty acid profile of both total plasma and PLs was determined by gas chromatography. High pressure liquid chromatography was used to quantitate the tocopherol isomers and retinol (vitamins E and A, respectively). The anorexic patients showed below normal weight-for-height, decreased percent body fat, and a high incidence of secondary amenorrhea. Of the four tocopherol isomers measured, only the beta + gamma fraction was significantly lower than the normal value. The essential fatty acids, linoleate and linolenate, were lower in the PL fraction of the anorexic group; linolenate, none detected. Other indicators of essential fatty acid status differed from the normal group in the direction of deficiency. Eicosatrienoic acid, however, was not detected in either group. These findings indicate that patients with anorexia nervosa are low in circulating essential fatty acids and, consequently, are potentially at risk for developing clinical signs of essential fatty acid deficiency if their restricted food intake is severe and prolonged. (A uthor)
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