Acute effects of various carbohydrates on brain serotonin metabolism and catecholamines of rats
1988
Yokogoshi, H.
Various kinds of starches (corn, potato, rice, sweet potato and wheat) caused the increases of the concentrations of serum insulin, brain tryptophan and serotonin. Fructose did not induce the serum insulin and also brain 5-hydroxyindoles. Pargyline, an inhibitor of monoamine oxidase, caused a significant accumulation of brain serotonin levels, and glucose plus pargyline caused a furthermore elevation of brain serotonin as compared to a pargyline control. Parachlorophenylalanine, an inhibitor of serotonin synthesis at the tryptophan hydroxylase, reduced the concentrations of brain serotonin and 5-hydroxyindole acetic acid (5HIAA), but the concomittant administration of glucose did not affect these levels. Glucose administration did not change the catecholamine levels in hypothalamus. These observations indicate that, when rats were fed the high carbohydrate diet, insulin affects the regulation of brain 5-hydroxyindoles, and the increase of brain serotonin may not be due to the changes of metabolism (synthesis or degradation of serotonin) but be due to the changes of precursor supply into brain.
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