Embryotoxicity of 4-deoxynivalenol (vomitoxin) in mice
1982
Khera, K.S. | Whalen, C. | Angers, G. | Vesonder, R.F. | Kuiper-Goodman, T.
The teratogenic potential of vomitoxin is at present unknown, therefore this study was conducted to assess the embryotoxic effects of vomitoxin in pregnant mice. In this study vomitoxin manifested a specific lethal effect on the mouse embryo associated with or without maternal vaginal bleeding but with no apparent maternal toxicity at the 2.5, 5, 10 and 15 mg/kg doses. Multiple teratogenic effects occurred at the 2.5 and 5 mg/kg doses but no adverse effects were observed at the 0.5 mg/kg dose.
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