Nutritional manipulations and tumor growth. II. The effects of intravenous feeding
1979
Due to the increased use of total parenteral nutrition (TNP) to override the hypophagia of a cancer-bearing host, understanding the competition for nutrients between the tumor and the host has become very important. Rats, 32 with sarcomas and 29 normal, were assigned to a chow, TPN, dextrose, or an amino acid diet or to starvation for 5 days. On the 4th and 5th days, the fed and TPN groups showed no difference in daily weight gain, whereas the other 3 groups had daily loss. The TPN group's total body water content decreased relative to fed animals. The tumor group had decreased nitrogen retention. Tumor growth was unaffected by the difference in diets, as measured by volume, weight, nitrogen, DNA content, and water content. Hyperglycemia developed in the TPN and dextrose groups of rats with and without. Liver weight to total body ratio was significantly higher with intravenous feeding, and fat disposition increased and water content decreased. The moderate excess nutrients of TPN did not increase tumor growth but did conserve carcass mass.
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