Humoral recognition of lipopolysaccharide core antigens of gram-negative bacteria in neonatal swine

Humoral recognition of lipopolysaccharide core antigens of gram-negative bacteria in neonatal swine

1989

Serologic recognition of common lipopolysaccharide core antigens has been related to enhanced resistance to gram-negative bacterial disease in several species. Class-specific titers (IgG, IgM) were determined by direct ELISA, using intact Escherichia coli (J5) as a plate antigen. Serum samples were obtained from 224 neonatal swine between the ages of 36 and 60 hours. The mean (+/- SEM) log(10) IgG titer against gram-negative core antigens was 1:1,713 +/- 0.4718 and the mean log(10) IgM titer was 1:202 +/- 0.5644. The IgG titer was directly related with litter size, birth weight, and serum total IgG concentration; IgM titer was directly related with dam parity and serum total IgG concentration.

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