Salvifarinin A, a neo-clerodane diterpenoid with a 6/5/7 tricyclic skeleton from Salvia farinacea
2018
Fan, Min | Chen, Xue-Jiao | Wu, Xing-De | Shao, Li-Dong | Ji, Xu | Zhao, Qin-Shi
Salvifarinin A (1), a rearrangement product of Languidulane-type clerodane diterpenoids with a 6/5/7 tricyclic ring skeleton fused with γ-lactone ring and furan ring, and two new biogenetically related diterpernoids, salvifarinins B (2) and C (3), were isolated from the aerial parts of Salvia farinacea. The absolute configuration of 1 was elucidated by extensive spectroscopic methods, and confirmed by single crystal X-ray diffraction and bio-inspired semisynthesis. The plausible biogenetic pathway was also proposed. Compound 2 displayed a potent effect on reducing hepatic steatosis.
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