β₁ and β₃ integrins disassemble from basal focal adhesions and β₃ integrin is later localised to the apical plasma membrane of rat uterine luminal epithelial cells at the time of implantation
2011
Kaneko, Yui | Lecce, Laura | Day, Margot L. | Murphy, Christopher R.
The present study investigated the expression of integrin subunits that are known to be associated with focal adhesions, namely β₁ and β₃ integrins in rat uterine luminal epithelial cells during early pregnancy. The β₁ and β₃ integrins were concentrated along the basal cell surface and were colocalised and structurally interacted with talin, a principal focal adhesion protein, on Day 1 of pregnancy. At the time of implantation, β₁ and β₃ integrins disassembled from the site of focal adhesions, facilitating the removal of uterine luminal epithelial cells for embryo invasion. Also at this time, β₃ integrin markedly increased along the apical membrane, suggesting a role in embryo attachment. This distributional change in β₁ and β₃ integrins seen at the time of implantation was predominantly under the influence of progesterone. Taken together, β₁ and β₃ integrin disassembly from focal adhesions and the increase in β₃ integrin apically are key components of hormonally regulated endometrial receptivity.
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