The antifungal metabolites obtained from the rhizospheric Aspergillus sp. YIM PH30001 against pathogenic fungi of Panax notoginseng
2014
Liu, Kai | Zheng, Youkun | Miao, Cuiping | Xiong, Zijun | Xu, Lihua | Guan, Huilin | Yang, Yabin | Zhao, Lixing
Eight anthraquinones (1–8), three xanthones (11–13) and two phenols (9–10) were isolated from Aspergillus sp. associated with Panax notoginseng , and their structures were determined as ziganein-1-methyl ether (1), 8- O -methylchrysophanol (2), averythrin (3), averufin (4), 8- O -methyl averufin (5), versicolorin B (6), averantin (7), methyl-averantin (8), arugosin C (9), diorcinol (10), sterigmatocystin (11), demethylsterigmatocystin (12) and dihydrosterigmatocystin (13) by spectroscopic analyses. Compounds 1 , 2 and 5 were the novel isolates from genus Aspergillus . Compounds 3 , 6 and 7 exhibited antifungal activity against Fusarium solani , pathogenic fungus of P. notoginseng , with minimum inhibitory concentrations (MICs) of 16 – 32 μg/mL, and compounds 1 , 3 , 4 , 7 and 9 showed antibacterial activity against Bacillus subtilis with MICs of 64–128 μg/mL, 16–32 μg/mL, 8–16 μg/mL, 16–32 μg/mL and 64–128 μg/mL, respectively. The metabolites showed the potential value in the research of antifungal agents, especially in searching for a biocontrol of diseases of P. notoginseng . The preliminary structure–activity relationships have been discussed for some of the compounds.
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