Gold Nanoparticle-Bridge Array to Improve DNA Hybridization Efficiency of SERS Sensors
2022
Huang, Xiaobin | Zhao, Weidong | Chen, Xiangyu | Li, Jinming | Ye, Haochen | Li, Cancan | Yin, Xiaomeng | Zhou, Xinyuan | Qiao, Xuezhi | Xue, Zhenjie | Wang, Tie
The interfacial mass transfer rate of a target has a significant impact on the sensing performance. The surface reaction forms a concentration gradient perpendicular to the surface, wherein a slow mass transfer process decreases the interfacial reaction rate. In this work, we self-assembled gold nanoparticles (AuNPs) in the gap of a SiO₂ opal array to form a AuNP-bridge array. The diffusion paths of vertical permeability and a microvortex effect provided by the AuNP-bridge array synergistically improved the target mass transfer efficiency. As a proof of concept, we used DNA hybridization efficiency as a research model, and the surface-enhanced Raman spectroscopy (SERS) signal acted as a readout index. The experimental verification and theoretical simulation show that the AuNP-bridge array exhibited rapid mass transfer and high sensitivity. The DNA hybridization efficiency of the AuNP-bridge array was 15-fold higher than that of the AuNP-planar array. We believe that AuNP-bridge arrays can be potentially applied for screening drug candidates, genetic variations, and disease biomarkers.
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