A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5
2017
Liu, Chong-Xi | Liu, Shuang-He | Zhao, Jun-Wei | Zhang, Ji | Wang, Xiang-Jing | Li, Jian-Song | Wang, Ji-Dong | Xiang, Wen-Sheng
A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC ₅₀ values of 9.7, 12.8, and 9.1 μg/ml, respectively, which was relative higher than that of spectinabilin.
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