Facile synthesis of bifunctional silica-coated core–shell Y₂O₃:Eu³⁺,Co²⁺ composite particles for biomedical applications
2012
Atabaev, Timur Sh | Jin, Oh Seong | Lee, Jong Ho | Han, Dong-Wook | Vu, Hong Ha Thi | Hwang, Yoon-Hwae | Kim, Hyŏng-guk
In the present study, bifunctional silica-coated Y₂O₃:Eu³⁺,Co²⁺ spherical-shaped submicron composite particles were successfully prepared using a facile urea-assisted homogenous precipitation method. Synthesized Y₂O₃:Eu³⁺,Co²⁺ phosphor composites showed both ferromagnetic behaviour and strong visible red luminescence emission. The surface of the Y₂O₃:Eu³⁺,Co²⁺ phosphor composites was modified with a thin silica layer to enhance the luminescent properties and obtain higher biocompatibility of the samples. The composite particles with silica coatings resulted in a small decrease in the viability of L-929 fibroblastic cells at concentrations lower than 25 ppm and allowed cell imaging via internalization and wide distribution into the cells. Overall, these synthesized novel SiO₂@Y₂O₃:Eu³⁺,Co²⁺ core–shell phosphor composites with both magnetic and luminescent properties have potential biomedical applications, including bioimaging and diagnosis, and can be also potentially used as MRI contrast agents.
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