BMP7 is a candidate gene for reproductive traits in Yorkshire sows
2020
Du, Xing | Yin, Hang | Pan, Zengxiang | Wu, Wangjun | Shang, Peng | Chamba, Yongzom | Li, Qifa
Bone morphogenetic protein 7 (BMP7) is of the BMP subfamily, and has effects on female fertility by regulating steroidogenesis, granulosa cell states, and follicular development. In the present study, there was assessment of the combined genotypes formed by the three variants within the 3′-UTR of BMP7 gene as associations with sow reproductive functions. The 3′-UTR of the BMP7 gene of pigs was identified using the 3′ RACE assay, and its full-length sequence was found to be 1538 bp in length. Multiple RNA regulatory elements were detected in this region, luciferase activity assays were performed and results indicated miR-22−3p affects BMP7 by directly binding to the miRNA response element in the 3′-UTR (c.2358–2382). In addition, two novel complete linkage variants, c.2256 G > C and a 7-bp indel (c.2259–2265), were identified within the 3′-UTR of the BMP7 gene of pigs. Importantly, combined genotypes with these two novel variants and c.1569A > G, a variant previously identified in the BMP7 3′-UTR of pigs, were associated with sow reproductive traits, including the total number of piglets born, number of dead piglets at birth, and litter weight in the Yorkshire pig population studies. Results from the present study confirm that BMP7 is a candidate gene for the reproductive traits in Yorkshire sows.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par National Agricultural Library
Découvrez la collection de ce fournisseur de données dans AGRIS