In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs)
2011
Liu, Hongling | Hu, Wei | Sun, Hong | Shen, Ouxi | Wang, Xinru | Lam, Michael H.W. | Giesy, John P. | Zhang, Xiaowei | Yu, Hongxia
The potential of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and its related hydroxylated analogs (2′-HO-BDE28, 6-HO-BDE47, 4′-HO-BDE17, and 4′-HO-BDE49) to modulate estrogen/thyroid/androgen receptor-(ER, TR, AR), mediated responses were investigated by use of reporter gene assays. Exposure to 1 or 10μM, 4′-HO-BDE17 significantly up-regulated expression of Luc, whereas other four chemicals did not induce Luc expression under control of the ER. Anti-estrogenic potency was observed for 4′-HO-BDE17 (IC50=1.14μM)>6-HO-BDE47 (IC50=2.65μM)>2′-HO-BDE28 (IC50=9.49μM)>BDE47 (IC50=21.11μM). No anti-estrogenic effect of 4′-HO-BDE49 was observed. Both 4′-HO-BDE17, 4′-HO-BDE49 resulted in greater responses of Luc expression induced by T3. BDE47, 2′-HO-BDE28, 6-HO-BDE47 did not show any effect on the expression of Luc induced by 5nM T3. 6-HO-BDE47 (IC50=0.34μM)>4′-HO-BDE17 (IC50=1.41μM)>BDE47 (IC50=3.83μM)>2′-HO-BDE28 (IC50=29.22μM) exhibited anti-androgenic potency, while 4′-HO-BDE49 did not show androgenic transcriptional activity.
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