Inhibition of fungal growth by selected sesquiterpene lactones
1993
Picman, A.K. | Schneider, E.F.
Three groups of sesquiterpene lactones, each with two closely related compounds, were examined for their effects of hyphal growth of three agriculturally important fungal pathogens. The most biologically active pair was alantolactone and isoalantolactone which, at the minimum inhibitory concentration (MIC) of 1 to 5 ppm, significantly inhibited growth of four isolates of Fusarium graminearum and two of each of Verticillium albo-atrum and Leptosphaeria maculans. Growth of the eight isolates also was significantly inhibited by 1 to 5 ppm of leptocarpin but related hydroxyleptocarpin was much less active, having MIC values 10 to 50 fold higher. The MIC value for each of the third pair of sesquiterpene lactones, parthenin and coronopilin, was 1 ppm for three isolates and 100 ppm for one isolate. Growth of a highly virulent isolate of V. albo-atrum was less sensitive than a weakly virulent isolate to parthenin and coronopilin.
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