Novel Sca-1+ macrophages modulate the pathogenic progress of endotoxemia
2020
Park, Min Young | Kim, Hyung Sik | Jeong, Yu Sun | Kim, Hye Young | Bae, Yoe-Sik
Macrophages are important innate immune cells that play crucial roles in inflammatory responses. Accumulating evidence has demonstrated macrophage heterogeneity based on biomarkers, functions, and localization. Here, we report a novel stem cell antigen-1 (Sca-1)-positive macrophage population induced in the pathological conditions caused by lipopolysaccharide (LPS). Sca-1 is only upregulated in macrophages but not in monocytes and neutrophils upon LPS injection. Sca-1⁺ macrophages develop from resident peritoneal macrophages. LPS-induced Sca-1⁺ macrophage generation was partly blocked by anti–IFN–γ antibody, suggesting a role of IFN-γ in the process. LPS-stimulated production of IL-6, TNF-α, and CCL2 is significantly lower in Sca-1⁺ macrophages compared to their counterpart Sca-1⁻ macrophages. Depletion of Sca-1⁺ macrophages using anti-Sca-1 antibody significantly increased survival rate and reduced lung and kidney damage in an LPS-induced sepsis model. Taken together, we discovered a novel population of Sca-1⁺ macrophages in LPS-induced septic conditions.
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