Natural Antioxidant, Chlorogenic Acid, Protects Against DNA Breakage Caused by Monochloramine
1999
SHIBATA, Hitoshi | SAKAMOTO, Yuji | OKA, Mikiko | KONO, Yasuhisa
Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, form I→form II→form III, induced by 3 mM monochloramine with a half inhibition of 67.4 μM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.
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