Biohydrogels Interpenetrated with Hydroxyethyl Cellulose and Wooden Pulp for Biocompatible Materials
2014
Tovar-Carrillo, Karla Lizette | Tagaya, Motohiro | Kobayashi, Takaomi
Biohydrogel interpenetrated films of wooden pulp cellulose and hydroxyethyl cellulose (HEC) were prepared, and their biomedical properties were investigated. Our purpose was to obtain new material combining the nontoxicity and biocompatibility in wooden pulp cellulose films by interpenetration of HEC. It was found that the increment of HEC content affects the mechanical properties of the hydrogel from 10 to 50 wt % content of HEC. In vitro biocompatibility tests showed that protein adsorption, clotting time, and platelet adhesion were affected with the increment of HEC. All of the obtained hydrogels showed better cytocompatibility than the reference on a tissue culture grade polystyrene dish. However, HEC content seemed to decrease fibroblast cell densities due to its effect on the film properties, showing different pulp aggregation. In conclusion, the cell densities on hydrogel were significantly changed depending upon the HEC interpenetration.
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