Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats
2014
da Silva, Victor Hugo Pereira | de Moura, Carolina Foot Gomes | Ribeiro, Flavia Andressa Pidone | Cesar, Augusto | Pereira, Camilo Dias Seabra | Silva, Marcelo Jose Dias | Vilegas, Wagner | Ribeiro, Daniel Araki
The aim of this study was to evaluate cytotoxicity and genotoxicity in multiple organs of rats induced by municipal effluent released by submarine outfall in city of Santos. A total of 20 male Wistar rats were exposed to effluents by drinking water ad libitum at concentrations of 0, 10, 50, and 100 % for 30 days. Microscopic analysis revealed severe lesions such as necrosis and hemorrhagic areas in liver and kidney from animals exposed to effluent at 50 and 100 % concentration. DNA damage in peripheral blood, liver, and kidney cells were detected by comet assay at higher concentrations of effluent. Moreover, a decrease DNA repair capacity was detected in liver cells. Significant statistical differences (p < 0.05) for micronucleated cells from liver were noticed at 50 % concentration of effluent. Taken together, our results demonstrate that municipal effluent is able to induce cytotoxicity and genotoxicity in multiple organs of Wistar rats.
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