New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract
2010
Meot-Duros, Laetitia | Cérantola, Stéphane | Talarmin, Hélène | Le Meur, Christophe | Le Floch, Gaëtan | Magne, Christian
Bioassay-guided fractionation of a chloroformic extract obtained from Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening microplate bioassay. Falcarindiol strongly inhibited the growth of Micrococcus luteus and Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50 μg ml−1. Moreover, this compound showed cytotoxicity against IEC-6 cells with an IC50 value of 20 μM after 48 h of exposition. These results suggest that Crithmum maritimum could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics, confirming the interest in studying halophytic species as sources of bioactive compounds.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par National Agricultural Library
Découvrez la collection de ce fournisseur de données dans AGRIS