Haematological, serobiochemical and immunological studies in diclofenac fed experimental Japanese quails
2010
Singh, S.K. | Srivastava, A.K. | Kumar, Sanjiv
The present work was conducted on Japanese quails which were fed diclofenac sodium for a period of 60 days. Haematological and serobiochemical observations were carried out on day 15, 30, 45 and 60. The statistical analysis of the mean values of hemoglobin, PCV and TEC revealed significant decrease. DLC showed gradual increase in heterophil and lymphocyte counts. The values of creatinine, uric acid, urea and BUN showed significant increases with significant decreases in the mean values of albumin and total protein. Differences were not observed in the mean values of ALT and AST at all the intervals. Immune response was measured by DNCB test. Significant decrease in the thickness of skin at all the intervals of DNCB post challenge was observed in toxicity group. It was concluded that diclofenac causes marked toxicity to the visceral organs particularly renal dysfunction and poor reactivities of host to the mitogen by cell mediated immune response.
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