Protective effect of Uncaria tomentosa extract against oxidative stress and genotoxicity induced by glyphosate-Roundup® using zebrafish (Danio rerio) as a model
2018
Santo, GlauciaDal | Grotto, Alan | Boligon, AlineA. | Da Costa, Bárbara | Rambo, CassianoL. | Fantini, EmilyA. | Sauer, Elisa | Lazzarotto, LuanM. V. | Bertoncello, KanandraT. | Júnior, OsmarTomazelli | Garcia, SolangeC. | Siebel, AnnaM. | Rosemberg, DenisB. | Magro, JacirDal | Conterato, GreicyM. M. | Zanatta, Leila
Oxidative stress and DNA damage are involved in the glyphosate-based herbicide toxicity. Uncaria tomentosa (UT; Rubiaceae) is a plant species from South America containing bioactive compounds with known beneficial properties. The objective of this work was to evaluate the antioxidant and antigenotoxic potential of UT extract in a model of acute exposure to glyphosate-Roundup® (GR) in zebrafish (Danio rerio). We showed that UT (1.0 mg/mL) prevented the decrease of brain total thiols, the increase of lipid peroxidation in both brain and liver, and the decrease of liver GPx activity caused after 96 h of GR (5.0 mg/L) exposure. In addition, UT partially protected against the increase of micronucleus frequency induced by GR exposure in fish brain. Overall, our results indicate that UT protects against damage induced by a glyphosate-based herbicide by providing antioxidant and antigenotoxic effects, which may be related to the phenolic compounds identified in the extract.
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