Microwave-assisted guanidinylation in solid phase peptide synthesis: comparison of various reagents
2014
Witkowska, Ewa | Kubik, Karolina | Krosnicka, Jolanta | Grabowska, Karolina | Niescioruk, Anna | Wilenska, Beata | Misicka, Aleksandra
The guanidinylation of a peptide chain on a polymeric support under microwave conditions using derivatives of thioureas—S-alkylisothioureas, pyrazole-carboxamidine, and guanidine as guanidinylating reagents is described. The best results are obtained with N,N′-di-Z-S-methylisothiourea and N,N′-di-Z(2-Cl)-S-methylisothiourea. It is found that guanidinylation with reagents containing Boc groups is accompanied by side reactions.
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