Tyrosyluria in marasmus
1979
Dhatt, P.S. | Saini, A.S. | Guptā, Indu | Mehta, H.C. | Singh, Harjit
Plasma tyrosine and urinary levels of tyrosine metabolites were measured in 30 patients with marasmus and compared with 20 normal controls. In marasmus subjects, levels of tyrosine and metabolites were significantly higher than controls, although only 13.3% of patients had clinical tyrosyluria. Excess tyrosine inhibits the activity of oxidizing enzymes of tyrosine metabolites, but ascorbic acid maintains some enzyme activity. In this experiment, ascorbic acid reduced urinary excretion of one tyrosine metabolite. These findings suggest that tyrosyluria associated with marasmus may be due to ascorbic acid deficiency, resulting in reduced activity of hepatic enzymes. Urinary excretion of the tyrosine metabolite, p-hydroxyphenol acetic acid, appears to be a useful indicator for tyrosyluria.
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