Effects of equine infectious anemia virus on hematopoietic progenitors in vitro

Swardson, C.J.; Kociba, G.J.; Perryman, L.E.

Effects of equine infectious anemia virus on hematopoietic progenitors in vitro

1992

Swardson, C.J. | Kociba, G.J. | Perryman, L.E.

Direct effects of equine infectious anemia virus (EIAV) on hematopoiesis in vitro were studied. Bone marrow mononuclear cells from clinically normal horses were incubated with 100 TCID50 of EIAV/10(7) cells. These cells were cultured to assay for colonies derived from erythroid progenitors, granulocyte/monocyte progenitors, and fibroblastic progenitors. The EIAV had a selective suppressive effect on the erythroid progenitors. Colony-forming units-erythroid were suppressed to 80% of that for medium controls (P = 0.011). Burst-forming units-erythroid were suppressed to 70% of that for medium controls (P = 0.003). Significant effect was not apparent on colony-forming units-granulocyte/macrophage or on colony-forming units-fibroblastic.

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Mots clés AGROVOC

animals cells fibroblasts granulocytes hematopoiesis horses in vitro macrophages microbiology physiology

Informations bibliographiques

Publié dans

American journal of veterinary research

Volume 53 Numéro 7 Pagination 1176 - 1179 ISSN 0002-9645

D'autres materias

Hematopoietic stem cells; Equine infectious anemia virus; Late erythroid progenitors; Fibroblastic progenitors; Infectious anemia virus; Equine; Bone marrow cells; Bone marrow cells; Cultured; Early erythroid progenitors

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

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