Hasubanan alkaloids with anti-inflammatory activity from Stephania longa
2022
Liu, Hui | Liao, Wan-Qin | Lin, Rong-Xiao | Fan, Lixia | Sun, Jinyan | Chen, Hong-Yuan | Liu, Fang | Yang, An-Ping
Two new hasubanan alkaloids, stephalonester A (1) and stephalonester B (2), together with four known compounds, stephalonine E (3), longanone (4), cephatonine (5), and prostephabyssine (6) were isolated from the whole plant of Stephania longa. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR, ECD calculations, as well as by comparison with literature values. All compounds were evaluated for their anti-inflammatory activity in vitro. Compounds 4, 5, and 6 exhibited significantly inhibitory effects on TNF-α and IL-6 production with IC₅₀ values range from 6.54 to 30.44 µM.
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