New compounds from the aerial parts of Justicia gendarussa Burm.f. and their antioxidant and anti-inflammatory activities
2021
Zhang, Hai-Xin | Xia, Zhao | Xu, Tian-Qi | Chen, Yi-Min | Zhou, Guang-Xiong
Three new compounds (1–3), together with six known compounds (4–9), were isolated from the ethyl acetate fraction of ethanol extract of the aerial parts of Justicia gendarussa Burm.f. All of these known compounds were isolated from the plant for the first time. Their structures including absolute configurations were elucidated on the basis of HR-ESI-MS, NMR spectroscopic analyses, single crystal X-ray diffraction and comparison with the literatures. Compounds 1–9 were tested for their antioxidant and anti-inflammatory activities. Compounds 5 and 8 showed the antioxidant activities with IC₅₀ values of 28.61 ± 1.56 and 22.55 ± 1.38 μM, respectively. Compounds 2 and 3 showed anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC₅₀ values of 20.95 ± 1.11 and 16.50 ± 1.04 μM, respectively.
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