Ecdysteroid antagonists (cucurbitacins) from Physocarpus opulifolius (rosaceae)
1999
Sarker, S.D. | Whiting, P. | Sik, V. | Dinan, L.
Methanolic extracts of seeds of 4 species in the genus Physocarpus antagonise the action of the insect steroid hormone 20-hydroxyecdysone on a Drosophila melanogaster permanent cell line. The active components in the extract of P. opulifolius (ninebark) have been identified as cucurbitacin D, cucurbitacin F and 3-epi-isocucurbitacin D. The potencies of the individual cucurbitacins have been determined as 5 x 10(-7), 8 x 10(-7) and 7 x 10(-6) M, respectively (versus 5 x 10(-8) M 20-hydroxyecdysone). The distribution of antagonistic activity in plants of P. opulifolius has been assessed and HPLC/bioassay has been used to determine the chromatographic profiles of antagonist activity in parts of the growing plant.
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