Impacts of chloramine‐T treatment on antioxidant enzyme activities and genotoxicity in rainbow trout, Oncorhynchus mykiss (Walbaum)
2014
Boran, H | Altinok, I
Juvenile rainbow trout Oncorhynchus mykiss (Walbaum) were exposed to therapeutic, and higher concentrations of chloramine‐T (Cl‐T) to assess the effects of this chemical on the antioxidant enzyme system and genetic structure. Red blood cells acetylcholinesterase, ∆‐aminolevulinic acid dehydratase, paraoxonase and liver glutathione S‐transferase activity were increased at 10 and 20 mg L⁻¹Cl‐T‐exposed fish, while they were decreased at 30 mg L⁻¹Cl‐T‐exposed fish. On the other hand, liver catalase activity and liver protein levels increased at 10 mg L⁻¹and decreased at 20 and 30 mg L⁻¹concentrations of Cl‐T. Liver super‐oxide dismutase activity decreased at 10 mg L⁻¹and 20 mg L⁻¹Cl‐T and increased at 30 mg L⁻¹of Cl‐T. Compared to control, comet assay indicated that Cl‐T did not cause significant DNA damage to red blood cells of the fish. Results indicate that 10 or 20 mg L⁻¹Cl‐T can be safely used to prevent or treat external parasitic and bacterial infection of rainbow trout.
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