Comparative QSAR: understanding hydrophobic interactions
1995
Hansch, C.
In our current database of 3000 bio QSAR less than 10% lack hydrophobic terms. It is of particular interest that some of these are for QSAR in whole organisms. Various examples are given. A surprising number involve electrophiles. Also in instances where reaction has been shown to occur with a receptor without apparent hydrophobic interactions, the same effect is present in the QSAR for the cell or organism.
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