Synthesis of spiroketal-modified avermectin analogs: 23-nor-23-oxa- and 23-nor-23-thia-avermectins
1994
Meinke, P.T. | O'Connor, S.P. | Fisher, M.H. | Mrozik, H.
The concise synthesis of avermectin analogs wherein the C23 carbon has been excised and replaced with an oxygen or sulfur atom is described. The new, heteroatom-substituted avermectins represent isosteres of 22,23-dihydro-avermectin B1a and, in the case of the sulfoxides and sulfones, are isosteric to avermectin B2a. These new avermectins bear diverse functionality at C24 and C25.
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